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In contrast, seven other mRNA modifications, such as O 6 -methylguanosine, O 4 -methyluridine, m 1 A, N 3 -methyladenosine, N 3 -methylcytidine, N 1 -methylguanosine, m 7 G, 8-oxo-7,8-dihydroguanosine, and 8-oxo-7,8-dihydroadenosine, result from oxidation, alkylation, or UV radiation and are less frequent [15]