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Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6307-6312

Gaballa SA, et al

(Lausanne) 14 , 1085799 (2023)

Research indicates that Protein tyrosine kinase 2 (PTK2) stimulates the accumulation of -catenin in the nucleus of HCC cells, thereby increasing Wnt/-catenin signaling pathway activity, and in this way promoting stemness of CSCs and enhancing the tumorigenicity of HCC cells (109)