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For the researchers, parenteral high-dose thiamine was effective in reversing Parkinsons disease symptoms, that a dysfunction of thiamine-dependent metabolic processes could cause selective neural damage in the centers typically affected by this disease and that Thiamine could have both restorative and [nerve-protecting] action in Parkinsons disease. Source: Costantini, Antonio, Maria Immacolata Pala, Enzo Grossi, Stella Mondonico, Luisa Ercoli Cardelli, Carina Jenner, Sabrina Proietti, Marco Colangeli, and Roberto Fancellu

Excessive Cu accumulation in the blood was found in the pathogenesis of atherosclerosis

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