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High expression of CD38 in immune cells can affect their functions, such as in macrophages, regulatory T cells (Tregs), regulatory B cells (Bregs), myeloid-derived suppressor cells (MDSCs) and CD16 - CD56 + natural killer (NK) cells ( + level

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To test whether TDP-43 SUMOylation is linked with disease-like states, we expressed ALS-linked mutant TDP-43 (TDP-43 Q331K ) and found that TDP-43 SUMOylation was significantly increased compared to wild type TDP-43 (Fig