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In chronic kidney disease, loss of kidney epithelial cells leads to glomerulosclerosis and tubular atrophy, whereas interstitial inflammation and fibrosis result from an excess of leukocytes and myofibroblasts

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Ethics declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Daping Hospital, Army Medical University (NO.2023-137-01)

For example, melatonin can not only directly clean ROS but also promote antioxidant enzymes such as GPx and glutathione reductase, thereby indirectly scavenging ROS