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For in vivo or ex vivo studies (if employed in nonclinical contexts), consider potential biodistribution, clearance, and off-target interactions in experimental design

But the inability to replicate meaningful results in a larger, longer trial raises legitimate questions about the magnitude and reliability of the fat loss effect

Figure 2 Serum vitamin B 12 and mortality 2125 participants incurred 835 deaths during a median 25.75 (IQR:19.25-26.83) years of follow-up

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