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doi: 10.3389/fmolb.2016.00027 Received 15 April 2016 Accepted 07 June 2016 Published 27 June 2016 Volume 3 - 2016 Edited by Thomas Ngele, University of Vienna, Austria Reviewed by Andrea Fuso, Sapienza University of Rome, Italy

Johns Wort can accelerate clearance and diminish efficacy, whereas inhibitors like ketoconazole, clarithromycin, certain protease inhibitors, or excessive grapefruit intake may elevate serum estradiol and increase adverse-event risk