bacterial glutathione peroxidase Simplified catalytic mechanism of the peroxidase: in the Concerted action of Glutathione peroxidase-1,

(2005) Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors

doi:10.1016/j.pneurobio.2014.11.004 Evidence-Base Disclosure The published evidence base for Dihexa consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

Growth hormone leads to IGF-1, and IGF-1 drives muscle protein synthesis through the mTOR pathway

However, this strategy is only attractive if the therapeutic agent itself is not a substrate for CPA, or if the case, that its functional activity is not negatively affected by C-terminal cleavage