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At the 12th week, the mice demonstrate significant hepatic steatosis, with blood alcohol concentrations (BACs) reaching 100150 mg/dL, accompanied by mild liver injury, albeit without apparent liver fibrosis (Zhu et al., 2022)

The reconstruction process incorporated tissue-specific expression data into the generic human metabolic network framework to produce context-specific models suitable for simulation

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Additionally, it activated the AMPK/SIRT1 signaling pathway and upregulated Nrf2 nuclear translocation, thereby enhancing the bodys antioxidant defense capacity (Figure 1 and Table 2)