glutathione alkylating agents Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Alkylating Agents - howMed

Keywords Bretylium Trade Name: generic Drug Class: Antiarrhythmic Mechanism of Action: (after an initial phase of causing the release of catecholamines) Interferes with the neuronal release of catecholamines Bretylium also lengthens the duration and effective refractory period in heart tissue (a Class III effect), an effect that is most pronounced in ischemic cells (which have shortened action potential durations) Indications: No longer available in the United States Previously used for attempted resuscitation from ventricular fibrillation after lidocaine and cardioversion have failed Side Effects: Precipitation of cardiac arrhythmias at the onset of drug therapy due to its ability to cause the initial release of catecholamines (when used as an antiarrhythmic)

Supportive medications Your doctor may prescribe you supportive medications like antiemetics (ondansetron, metoclopramide) for vomiting and nausea, antidiarrheals for diarrhea, and laxatives for constipation if these side effects do not subside over time

Glossary GLP-1 (Glucagon-Like Peptide-1) An incretin hormone produced in the gut that suppresses appetite, slows gastric emptying, and promotes insulin secretion

In summary, NAC transiently improved tissue oxygenation in about half of the patients with septic shock to whom it was administered