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In the CF-M and CF-L groups, the star-shaped and polygonal structures of some HP tubules disappeared, the lumen became larger, the epithelium became thinner, and B- and R-cells were compressed into oval shapes (Figure 2)

While this allowed larger sample sizes at earlier time points and the potential for longitudinal analysis in some animals (a fact that was ultimately not important), in the future, equalizing sample sizes may provide statistical simplicity, and allow a balanced correlation between US and IHC outcomes for a full data set

They administered a single dose of NMN (500 mg/kg i.p.) and found that NMN could prevent islet dysfunction in the model mice