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The myelin sheath is key to our nervous system

Conversely, extremely high hepcidin levels can result in iron sequestration and functional iron deficiency

MT-II was designed and characterised through the systematic melanocortin peptide structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona , the same programme that produced MT-1 , with the cyclisation strategy introduced to further constrain the pharmacophore into a receptor-binding conformation that simultaneously increases potency, metabolic stability, and the receptor subtype selectivity profile that distinguishes MT-II from the linear tridecapeptide MT-1

Upston JM, Kritharides L, Stocker R