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Certain factors such as high levels of markers of immune activation such as IL-4, IL-10, and TNF-, or cytokine release syndrome (CRS) in patients with COVID-19 and high levels of granulocyte colony-stimulating factor (G-CSF), IL-6, IL-7, IL-8, IL-10, IL-1R, IFN-, TNF-, granulocytemacrophage (GM)-CSF, and monocyte chemoattractant protein-1 (MCP-1) are of great importance in this malignancy

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In the same work, cystine availability was lower in autochthonous PDAC tumours compared with subcutaneous tumours, supporting the relevance of anatomical location for the metabolic microenvironment

doi: 10.1136/jitc-2019-000441 223 IzarBTiroshIStoverEHWakiroICuocoMSAlterIet al