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[DOI] [PubMed] [Google Scholar] 78.de lHortet AC, Takeishi K, Guzman-Lepe J, Morita K, Achreja A, Popovic B, et al

The phosphodiesterase-4 inhibitor ibudilast increases brain levels of glial-derived neurotrophic factor and reduces microglial activation and production of pro-inflammatory cytokines ( Vaccine Immunotherapies Immunotherapies reduce the amount of drug in the CNS by triggering the production of antibodies binding the drug molecule after systemic absorption of METH (White et al., 2014)