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As such, simulating FY 2023 and FY 2024 payments for this LTCH based on their FY 2022 claims results in simulated payment amounts that we do not believe are reasonable approximations of the payment amounts this LTCH will actually receive in FY 2023 and FY 2024

Administration of PPA@aPD-L1 to mouse models has remodelled the immunosuppressive landscape, characterised by increased CD8 + T cell infiltration and decreased Treg cell infiltration, through the inhibition of the NF-B and STAT3 pathways in tumour cells, compared to PPA or aPD-L1 alone [172]

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There's no first-pass metabolism issue, no gut enzyme exposure, no uncertainty about what percentage of the dose actually reaches target tissue