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GSTs are divided into 14 classes: phi (GSTF), tau (GSTU), theta (GSTT), zeta (GSTZ), lambda (GSTL), metaxin, hemerythrin (GSTH), iota (GSTI), glutathione-dependent dehydroascorbate reductase (DHAR), tetrachloro hydroquinone dehalogenase (TCHQD), -subunit classes of the eukaryotic translation elongation factor 1B (EF1B), glutathionyl hydroquinone reductase (GHR), GSTs with two thioredoxins (GST2N), and microsomal prostaglandin E synthase type 2 (mPGES2) 2,3

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The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content

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