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To test the O 2 production capacity of CCPCA NPs, A375 cells were seeded at a density of 8 10 3 cells/well and incubated with RDPP (0.1 M) and Hoechst (1 g mL 1 ) for 20 min

Science 241, 462464

ChaC1, as a tumor-influencing factor, enhances ER stress, contributing to necroptosis and ferroptosis of multiple cancers, including metastatic melanoma (64), breast (54), prostate (65) and primary liver cancer (66), Burkitt's Lymphoma (67), head and neck squamous cell carcinoma (68), glioblastoma multiforme (GBM) (69), oral squamous cell carcinoma, T lymphoblastic leukemia Molt4 cells and colitis-associated carcinogenesis (15)

T2DM and hyperglycemia are also associated with oxidative stress from the overproduction of reactive oxygen species (ROS) and decreased efficiency of scavengers systems (Collier et al., 1990