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Causes and considerations: Direct taste sensation from the copper-containing complex Post-nasal drip from nasal formulations Transient effect often mitigated with delivery technique adjustments The metallic taste is not typically a clinically meaningful adverse effect, but it can be bothersome enough that patients discontinue therapy

We diluted the siRNA transfection reagent with serum-free medium according to the reagent instructions to avoid the effect of serum on transfection efficiency

Pharmacokinetic studies of several bioactive compounds have demonstrated limited oral bioavailability, rapid metabolism, extensive first-pass hepatic clearance, and low systemic exposure

The rationale is further supported by several studies that demonstrated that the human gut microbiome is a major determinant of plasma metabolome, potentially playing a more dominant role than genetics