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Mechanisms of acquired resistance to first-and second-generation EGFR tyrosine kinase inhibitors

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These include alcohol consumption (Reference Grad, Abenavoli and L Dumitrascu48) and tobacco use (Reference Pandolfino and Kahrilas49) , obesity (Reference Yang, Lin and Li50) , particularly abdominal obesity (Reference Zhan, Yuan and Zhao51) , central nervous system depressants (Reference MacFarlane52) , pregnancy (Reference Ali, Hassan and Egan53) , hiatal hernia (Reference Sfara and Dumitracu54) , delayed gastric emptying (Reference Fass, McCallum and Parkman55) and increased gastric volume (Reference Newberry and Lynch13)