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Of note, it was counteraction of the leg contracture, which was assessed immediately after the intramuscular injection of succinylcholine, after the cessation of overt symptoms of muscle involvement, and then at the subsequent following days

The direction of treatment changed following the adverse outcomes highlighted by the Cardiac Arrhythmia Suppression Trial (CAST) and the Survival with Oral D-Sotalol (SWORD) trial, which demonstrated that patients receiving AADs (encainide or flecainide) fared worse than those on placebo (6)