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For instance, certain strains of Gram-negative Enterobacteriaceae , which are present in larger quantities in patients with PD, such as Escherichia coli and Salmonella , were found to secrete pro-inflammatory lipopolysaccharides (LPS), which are associated with more severe motor symptoms [134]

Yamaguchi T, Sano K, Takura K, Saito I, Shinohara Y, Asano T, et al

doi: 10.1046/j.1365-2958.2003.03849.X [DOI] [PubMed] [Google Scholar] Zhong J, Skouloubris S, Dai Q, Myllykallio H, and Barbour AG (2006)

In summary, chrononutrition approaches for older individuals emphasize synchronizing meals with circadian rhythms: eat during daylight and fast at night, maintain regular meal schedules, and incorporate foods that support circadian signals, rich in melatonin or its precursors