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However, the protective effect of internalization is limited, since treatments of 7 days or longer will all eventually induce analgesic tolerance [37, 78, 81, 82] independent of the degree of internalization triggered by the agonist

But yeah, I mean, you hear that all the time that people inject something, and there was more in it than they thought

As expected, stimulation of hippocampal neurons transfected with mRFP--actin with HGF, Dihexa and Nle1-AngIV had significantly enhanced dendritic arbors while those additionally transfected with she-Met RNA were no different from control treated neurons (FIG