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Long-Term Health Risks of Nicotine Outside of the well-established, long-term risks of tobacco use, a substantial body of research has also linked nicotine, including synthetic, to a wide variety of harmful health effects, including: Increased risk of heart attack and cardiovascular disorders Resistance to chemotherapy and higher risk of multiple cancer types Elevated risk of respiratory, gastrointestinal and kidney disorders High blood pressure and decreased immune response Negative impacts on reproductive health Long-lasting, life-threatening addiction Synthetic Nicotines Unique (and Unknown) Risks Because synthetic nicotine is still relatively new, very little data regarding its toxicity exists at this time, but many health experts are concerned about its potential impurities and unknown solvents

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