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Astrocytes also regulate the neuronal excitability by modulating tonic N -methyl-D-aspartate (NMDA) receptor currents, by releasing glycine and contributing to extracellular level of D-serine, both being allosteric co-agonists of NMDA receptors through the release of glutamate and contributing to extracellular levels of NMDA receptors 82,83

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Necroinflammation The inflammatory responses that emerge when cells die via inflammatory cell death modalities such as necroptosis or pyroptosis which trigger the uncontrolled release of cellular contents (so-called danger signals) into surrounding tissues leading to activation of immune cells that drive inflammation