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In one study toxicity manifested as tachycardia, central nervous system stimulation (restlessness and excitement), and vomiting did not occur until plasma theophylline concentrations reached 37 to 60 g/mL

Preferential formation of C3b-IgG complexes in vitro and in vivo from nascent C3b and naturally occurring anti-band 3 antibodies

Consistently with this kinetic, the presence of serum anti-nuclear antibodiesevidence for adaptive immune responsesdetected at first evaluation of Raynauds is considered an important, independent predictive element to classify Raynaud as secondary to SSc [68, 69]