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Unlike traditional viral vector-based methods for genetic modification, CRISPR-Cas9 offers two critical safety advantages, including elimination of insertional mutagenesis risks and precise gene editing without dependence on double-strand breaks

Eur Cytokine Netw 1998, 9: 205212

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In more severe patients in whom airway GSH reserves are depleted, this may result in a detrimental cascade with a shift toward GSSG formation and oxidation of thioredoxins, leading to post-translational protein modifications through oxidation of protein-methionine residues and formation of protein disulfides from glutathionylation or other mechanisms (Fig