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Mice on an ad libitum diet containing vitamin C increased induction of interferon (62145%) depending on the viral titer of inoculation (95), and L-ascorbate added to stimulated mouse cell lines increases interferon synthesis (96)

however, CHE has not been widely used in human clinical trials due to its shortcomings, such as drug toxicity

Front Endocrinol 5(10):750 Wongchitrat P, Shukla M, Sharma R, Govitrapong P, Reiter RJ (2021) Role of melatonin on virus-induced neuropathogenesisa concomitant therapeutic strategy to understand SARS-CoV-2 infection