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PCBP2: A secondary iron chaperone with specialized activities Although the initial genetic screen that produced PCBP1 as an iron chaperone did not identify other PCBP family members as potential iron chaperones, subsequent examination of the paralogous PCBP2, PCBP3, and PCBP4 suggested that they could also potentially have iron chaperone activity (Leidgens et al., 2013)

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While our study focused on endothelial K-Hcy-HMGB1/2-mediated senescence, K-Hcy modifications may constitute a novel pathological axis that disrupts multiple proteins and cellular processes, thereby driving ED through broader and previously unrecognized mechanisms

Elevated Sting expression was observed in bleomycin-induced mouse lung tissues, suggesting that bleomycin may induce pulmonary fibrosis through STING activation