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The mitochondrial creatine kinase isoform (mtCK), in particular, forms a multienzyme complex with the adenine nucleotide translocator (ANT) and the voltage-dependent anion channel (VDAC), effectively coupling mitochondrial ATP synthesis to cytosolic ATP utilization [11]

These data were in line with the hypothesis that neuromuscular junctions, which are the synapses between MNs and muscle fiber, could represent the starting site of MN dysfunction in ALS [269]

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By stabilizing drug bioavailability while reducing neutrophil activation, pro-inflammatory cytokine secretion, and osteoclast activity, the formulation minimizes gastrointestinal toxicity, offering superior efficacy in managing gout-related pain, joint destruction, and systemic complications compared to conventional oral therapies (Li Z