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The contribution of PRR to SSc pathogenesis has received increasing attention in two distinct directions: the role of PRR in the production of type I interferons (IFN-I) or other pro-inflammatory cytokines and the contribution of TLRs in activating mesenchymal cells, in particular fibroblasts

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(2013) and measures the similarity between two distributions by the integral over the squared difference between the two distribution functions: where F ( t ) and G ( t ) are the empirical cumulative distribution function of the modeled and reference-truth data, respectively, computed following the implementation outlined in Pulkkinen et al

May 31 2012;31(1):14