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Upon binding to leptin receptors (ObRs), leptin activates several signaling pathways, including Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, extracellular signal-regulated kinase 1/2 (ERK1/2) in the mitogen-activated protein kinase (MAPK) pathway, and IRS/PI3K/Akt pathway (69)

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Using imaging during the procedure can help make it more accurate