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3134 However, most of the previously reported MnO 2 -based nanozyme systems only have single or dual therapeutic modes, and their therapeutic effects are often limited by insufficient enhancement of oxidative stress and the lack of a synergistic mode for further enhancing and maintaining oxidative damage

The glyoxalase I and II which are responsible for catalyzing the conversion of methylglyoxal (a by-product in glycolysis) to lactic acid are among these enzymes [76]

In some cases, the encoded polypeptide is less than about 50 amino acids and the polypeptide is then referred to as a "peptide"

Discussion L1 GUS distribution across the SSN points to distinct substrate specificities We previously demonstrated that a small set of L1 GUS enzymes are capable of processing small glucuronide substrates and are susceptible to selective GUS inhibition, while non-L1 GUS enzymes process larger glucuronide-containing substrates and are not effectively inhibited 20,21