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Transport realism is another limitation: diffusion and binding in 3D matrices and chips may still differ from in vivo implants, and gradient design can bias outcomes unless standardized and benchmarked

The absence of a direct effect on the embryo is confirmed by studies of the penetration of trazodone through the placental barrier in rats: only minor concentrations of trazodone were found in embryonic tissues and amniotic fluid

For researchers considering these peptides, the practical implication is clear: start conservatively, monitor responses carefully, and do not assume that favorable research results guarantee individual outcomes

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