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Periodontal EDS (pEDS) is characterized by severe and intractable periodontitis of early onset (childhood or adolescence), lack of attached gingiva, pretibial plaques, and family history of a first-degree relative who meets clinical criteria Cardiac-valvular EDS (cvEDS) is characterized by severe progressive cardiac-valvular problems (aortic valve, mitral valve), skin problems (hyperextensibility, atrophic scars, thin skin, easy bruising), and joint hypermobility (generalized or restricted to small joints)

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That triggers several effects: Lowering blood sugar Keeping food in your stomach longer Sending signals from your brain that you are full and not hungry One of these drugs, Zepbound, mimics a second hormone, glucose-dependent insulinotropic polypeptide, that has additional effects on appetite