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[DOI] [PubMed] [Google Scholar] 24.de Morais SM, Wells PG

Neurologic symptoms The neurologic symptoms of vitamin B 12 deficiency are myriad and include numbness and tingling of the hands and, more commonly, the feet (peripheral neuropathy)

Due to their excellent biocompatibility, targeting ability, and high stability, they can serve as a potentially effective drug delivery system

However, there are still a lot of questions that remain to be answered about the relationship between folate levels in the colonic mucosa and the systemic circulation and the colorectal cancer risk, and about the role of folate derived from the diet and that from local microbial production 287,288,289,290