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We subsequently determined whether IPA enhances ISC proliferation in organoid assays, determining that no differences in colonic organoid formation and development were present between Veh- and IPA-treated mice at D0, indicating that IPA does not affect ISC proliferation ex vivo in the absence of DSS-induced injury

Inhibiting NNMT with 5-Amino-1MQ preserves intracellular NAD+ levels, which supports mitochondrial function and has been shown in rodent models to reduce adiposity and improve insulin sensitivity