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People who eat plant-based diets, take certain medications, or have gastrointestinal issues may struggle to absorb enough

Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community

The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)