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Current literature predominantly elucidates linker chemistries, cytotoxic payloads, and pharmacokinetics tailored to tumor biology (Long et al., 2025)

In the present study, this impaired GSH homeostasis was reflected in decreased plasma levels of pyroglutamic acid (GSH precursor) and increased erythroid levels of cysteinyl-glycine (GSH breakdown derivative)

More interestingly, injection of senescent cancer cells or dendritic cells activated by senescent cells in mice protects from tumor engraftment, induces significant tumor regression, and potentiates immunotherapies

For instance, a study on hepatocellular carcinoma demonstrated that an 8-oxoG modification at the third position of miR-122 promotes tumorigenesis, whereas further oxidation of the second nucleotide to yield 2,3o8G-miR-122 transforms it into a tumor-suppressive miRNA