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A holistic approach including hepatology, psychology and assessment of the underlying liver disease decreases alcohol consumption and promotes abstinence in patients with a suspected underlying ArLD as compared with a historical cohort Disclosures: Ares Villagrasa: Nothing to Disclose, Anna Aguilar-Amors: Nothing to Disclose, Sonia Carramiana: Nothing to Disclose, Carla Morer: Nothing to Disclose, Mireia Valle: Nothing to Disclose, Marta Selvi Blasco: Nothing to Disclose, Maria beda: Nothing to Disclose, Alba Jimenez-Massip: Nothing to Disclose, Marianela Guzman: Nothing to Disclose, Patricia lvarez-Lpez: Nothing to Disclose, Natalia Tumas: Nothing to Disclose, Francesc Belvis: Nothing to Disclose, Mariana Gutierrez-Zamora: Nothing to Disclose, Joan Benach: Nothing to Disclose, JuanManuel Perics: Nothing to Disclose, Meritxell Cots: Nothing to Disclose 1465 OBESITY AND ACUTE ALCOHOL-ASSOCIATED HEPATITIS: ADDING INSULT TO INJURY Yun-Cheng Hsieh 1 Mrigya Babuta 1 Hannah Siegenberg 1 Yunpeng Yu 2 Wanzhu Tu 2 Richard Sterling 3 Gyongyi Szabo 1 , 1 Beth Israel Deaconess Medical Center, 2 Indiana University, 3 Virginia Commonwealth University Background: Alcohol- associated hepatitis (AH) has high morbidity and mortality

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8,17,132-137 Given that ME/CFS symptoms recur in some improved patients who discontinue therapies, suggesting suboptimal clearance of the underlying pathology, there is increasing speculation that combinations may be more efficacious than single treatments