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3.4.3 BacA induce proliferation of CD8+, CD4+, and CD4CD45RO+ cells in calves at 16 weeks post-inoculation PBMCs from all treatment and control groups were analyzed by flow cytometry after stimulation with PPDa at 12-, 14- and 16-weeks post-inoculation, to evaluate the proliferation of CD4+, CD4+CD45RO+, CD8+, FOXP3+ and WC1+ T cell populations

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We extend beyond cataloging drugs by contextualizing landmark events such as the first biomarker-driven accelerated approval (tofersen) and a major Phase 3 trial failure leading to market withdrawal (AMX0035) to discuss their implications for clinical trial design and therapeutic strategy

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