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Areas with thinner skin, such as around the eyes or on the backs of hands, may show improvement earlier than areas with more significant laxity

GHK appears to support remodeling and restructuring of connective tissue, modulating expression of numerous genes, including up-regulation of genes of the TGF- pathway

F.TazearslanC.MerkurjevD.OhgiK.MeluzziD.et al (2025)

Studies where GHK was used for the healing of bone fractures in rats used a mixture of small molecules (Gly-His-Lys (0.5 g/kg), dalargin (1.2 g/kg) (an opioid-like synthetic drug), and the biological peptide thymogen (0.5 g/kg) (L-glutamyl-L-tryptophan)) to heal bones