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The molecular target that AOD-9604 actually binds is still unidentified, which the FDA explicitly noted in its December 2024 evaluation

A 500mcg daily protocol under split dosing would look like: 300mcg upon waking (fasted), then 200mcg approximately 30 minutes before dinner or before bed on an empty stomach

[8] While we await significant developments in the study of AOD-9604, keep in mind that although reduced cellulite and subcutaneous fat can have positive implications, it's crucial to pursue these goals in a healthy and balanced way, focusing on overall wellness rather than just appearance

Conversely, if a patient presents with pernicious anemia or severe neurological signssuch as intense tingling in the hands, memory loss, or muscle weaknessthe dosage remains the same (usually 1,000 mcg), but the frequency increases significantly