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This can be a problem because when the body produces an excessive amount of inflammatory eicosanoids, it results in more chronic inflammation, which is linked to many serious health problems

While several investigations have assessed heavy metal accumulation in freshwater species, most have been limited to quantification rather than evaluating the biological impact of these metals on the species

This pH normalization not only enhances the performance of pH-sensitive drugs but also exerts immunomodulatory effects, promoting macrophage polarization toward the pro-inflammatory M1 phenotype [284]

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