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For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush (Guo et al., 2022)

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In DDC mice, liver arachidonic acid (AA) concentration (by GC-MS) was increased, and RNA seq/qPCR showed suppression of mitochondrial STAT3 gene targets responsible for fatty acid oxidation and metabolism, all of which was reversed by GW4064

10.1016/j.meafoo.2024.100195 93 KeenumI.WindL.RayP.GuronG.ChenC.KnowltonK.et al (2022)