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10.1164/rccm.201305-0908LE Am J Respir Crit Care Med

The mutant enzyme mischarges tRNAAla with Gly or Ser, leading to amino acid misincorporation and protein misfolding, causing cerebellar Purkinje cell loss and ataxia, but not peripheral axon degeneration

While the initial trigger is nerve injury caused by the virus, ongoing pain often reflects a combination of persistent nerve sensitization and additional factors that continue to amplify pain signals

Ultrasound Obstet Gynecol 54(3):297307 Lucas D, Menez C, Girre C, Berthou F, Bodenez P, Joannet I et al (1995) Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects