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The underlying mechanism is as follows: oxidative phosphorylation, the TCA cycle, and the electron transport chain face inhibition due to an inadequate oxygen supply to brain tissue, alongside mitochondrial damage and dysfunction, leading to a marked decrease in ATP synthesis and overall energy metabolism impairment

In Arabidopsis , 20 AtGLRs grouped into three evolutionary clades have been characterized, yet the degree to which GLR-mediated signalling pathways are conserved across kingdoms remains unclear