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PEO was able to indirectly modulate the Hedgehog pathway by inhibiting the activation of the PI3K-Akt pathway and further reducing inflammation in UC ( 4.3 Regulation of autophagy and apoptosis By interacting with the PI3K/Akt signaling pathway, the herbal monomers and their metabolites showed significant efficacy in regulating autophagy and apoptosis in UC

Cell cycle stage-specific transcriptional activation of cyclins mediated by HAT2-dependent H4K10 acetylation of promoters in Leishmania donovani

However, these macromolecules are limited by their need for parenteral administration, which reduces patient compliance, increases healthcare costs, and complicates treatment logistics, especially for chronic conditions requiring frequent dosing

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