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In addition, the inflammatory response is also associated with other pathological aspects: for example, the release of pro-inflammatory cytokines such as IL-8 and TNF- from microglia leads to hypoxia-inducible factor- (HIF1)-dependent autophagic cell death (Takeda et al., 2021), microglia-secreted VEGF can be involved in angiogenesis (An et al., 2014), oxidative stress can trigger inflammatory injury via TLR4 (Gill et al., 2010), NLRP3 can be assembled via NF- kb assembles NLRP3 inflammatory vesicles and promotes caspase-1-mediated pyroptosis (Yang et al., 2019)

[34] An additional family utilizing an iron cofactor (FeSOD) has also been identified, which is evolutionarily related to MnSOD (Wolfe-Simon et al

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Figure 5 The highest betweenness values indicating high connectivity between clusters were represented by darker shades of blue, while the highest degree values (node degree) reflecting a high number of connections were represented by thicker node (proteins) borders ( Figure 5 )