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Vitamin B12 Deficiency Causes of vitamin B12 deficiency include difficulty absorbing vitamin B12 from food, lack of intrinsic factor (e.g., because of pernicious anemia), surgery in the gastrointestinal tract, prolonged use of certain medications (e.g., metformin or proton pump inhibitors), and dietary deficiency

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

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Most of these residues are conserved or replaced by similar amino acid residues in PfGrx or other enzymatically active glutaredoxins