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Similarly, treatment with naringin significantly increased rat body weight and various hematological parameters including hemoglobin, red blood cells, and platelet count, while decreasing spleen weight, colon weight, colon weight to length ratio, macroscopic score, adhesion score, diarrhea score, stool consistency, rectal bleeding score, and white blood cell count [153]

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Zinc and Vitamin C contribute to the maintenance of normal function of the immune system and zinc furthermore contributes to the protection of cell from oxidative stress.

Currently, the main agents used clinically include tolcapone, entacapone, and opicapone